Predicted to be involved in mitochondrial respiratory chain complex assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CHCHD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHCHD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHCHD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:55,919,468–55,920,026 | 292.0 kb | Distal (>10kb) Multiome | 374 | |
| chr8:56,073,616–56,075,349 | 137.2 kb | Distal (>10kb) Multiome | 1070 | |
| chr8:56,156,925–56,157,710 | 54.5 kb | Distal (>10kb) Multiome | 251 | |
| chr8:56,202,325–56,202,690 | 9.1 kb | Proximal (<10kb) | 102 | |
| chr8:56,210,270–56,212,762 | 227 bp | At TSS Multiome | 1021 | |
| chr8:56,220,819–56,220,993 | 9.0 kb | Proximal (<10kb) | 42 | |
| chr8:56,447,390–56,448,440 | 236.3 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the CHCHD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.