Transcription factors with Perturb-seq knockdown data for CHASERR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHASERR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHASERR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:92,634,312–92,635,219 | 247.9 kb | Distal (>10kb) Multiome | 57 | |
| chr15:92,647,486–92,648,715 | 234.7 kb | Distal (>10kb) Multiome | 186 | |
| chr15:92,655,159–92,656,121 | 227.1 kb | Distal (>10kb) Multiome | 425 | |
| chr15:92,667,223–92,667,908 | 215.3 kb | Distal (>10kb) Multiome | 251 | |
| chr15:92,711,051–92,711,898 | 171.2 kb | Distal (>10kb) Multiome | 157 | |
| chr15:92,714,124–92,715,096 | 168.0 kb | Distal (>10kb) Multiome | 524 | |
| chr15:92,808,119–92,810,229 | 73.4 kb | Distal (>10kb) Multiome | 1196 | |
| chr15:92,820,255–92,820,821 | 62.2 kb | Distal (>10kb) Multiome | 703 | |
| chr15:92,831,519–92,832,242 | 50.7 kb | Distal (>10kb) Multiome | 904 | |
| chr15:92,880,432–92,880,899 | 1.8 kb | Proximal (<10kb) | 38 | |
| chr15:92,881,916–92,883,525 | 139 bp | At TSS Multiome | 906 | |
| chr15:92,899,945–92,900,660 | 17.6 kb | Distal (>10kb) Multiome | 712 | |
| chr15:92,903,883–92,904,823 | 21.6 kb | Distal (>10kb) Multiome | 1080 | |
| chr15:93,029,697–93,031,417 | 148.1 kb | Distal (>10kb) Multiome | 387 | |
| chr15:93,061,337–93,062,093 | 179.1 kb | Distal (>10kb) Multiome | 112 | |
| chr15:93,072,427–93,074,030 | 190.5 kb | Distal (>10kb) Multiome | 430 | |
| chr15:93,087,724–93,089,709 | 206.6 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the CHASERR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.