Transcription factors with Perturb-seq knockdown data for CFAP92. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP92 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP92, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,698,248–128,698,988 | 295.5 kb | Distal (>10kb) Multiome | 239 | |
| chr3:128,725,886–128,726,915 | 268.0 kb | Distal (>10kb) Multiome | 900 | |
| chr3:128,832,889–128,833,369 | 160.9 kb | Distal (>10kb) Multiome | 38 | |
| chr3:128,845,614–128,846,390 | 148.1 kb | Distal (>10kb) Multiome | 538 | |
| chr3:128,878,828–128,880,293 | 114.6 kb | Distal (>10kb) Multiome | 1016 | |
| chr3:128,993,367–128,994,455 | 42 bp | At TSS Multiome | 344 | |
| chr3:129,001,013–129,002,370 | 6.9 kb | Proximal (<10kb) | 202 | |
| chr3:129,003,867–129,004,076 | 9.8 kb | Proximal (<10kb) | 280 | |
| chr3:129,027,026–129,027,525 | 33.1 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,045,697–129,046,752 | 52.5 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,120,244–129,122,947 | 127.9 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 167.3 kb | Distal (>10kb) Multiome | 917 | |
| chr3:129,183,284–129,184,525 | 189.8 kb | Distal (>10kb) Multiome | 966 | |
| chr3:129,249,227–129,250,064 | 255.4 kb | Distal (>10kb) Multiome HiCAR | 767 | |
| chr3:129,278,315–129,279,976 | 284.7 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the CFAP92 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.