Enables AMP binding activity. Involved in establishment of left/right asymmetry and flagellated sperm motility. Located in axonemal microtubule and sperm flagellum. Implicated in visceral heterotaxy 11. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFAP45. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP45 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP45, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,891,601–159,891,875 | 8.3 kb | Proximal (<10kb) | 325 | |
| chr1:159,891,987–159,893,486 | 6.7 kb | Proximal (<10kb) | 53 | |
| chr1:159,899,910–159,900,706 | at TSS | At TSS | 349 | |
| chr1:159,900,829–159,901,475 | 664 bp | At TSS | 103 | |
| chr1:159,909,082–159,909,741 | 8.9 kb | Proximal (<10kb) | 114 | |
| chr1:159,909,983–159,911,830 | 9.8 kb | Proximal (<10kb) | 438 |
Genomic view of the CFAP45 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.