Predicted to be involved in cilium assembly and flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CFAP161. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP161 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP161, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:80,989,298–80,990,315 | 144.4 kb | Distal (>10kb) Multiome | 780 | |
| chr15:81,000,317–81,003,329 | 133.4 kb | Distal (>10kb) Multiome | 865 | |
| chr15:81,133,906–81,134,755 | 16 bp | At TSS Multiome | 230 | |
| chr15:81,323,755–81,324,850 | 190.0 kb | Distal (>10kb) Multiome | 604 | |
| chr15:81,433,265–81,433,813 | 299.3 kb | Distal (>10kb) Multiome | 46 |
Genomic view of the CFAP161 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.