Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CERS6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CERS6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CERS6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:168,246,177–168,248,372 | 208.6 kb | Distal (>10kb) Multiome | 866 | |
| chr2:168,455,669–168,457,320 | 22 bp | At TSS Multiome | 1038 | |
| chr2:168,466,269–168,466,445 | 10.0 kb | Proximal (<10kb) | 48 | |
| chr2:168,470,408–168,471,271 | 14.7 kb | Distal (>10kb) Multiome | 161 | |
| chr2:168,552,291–168,552,797 | 96.3 kb | Distal (>10kb) Multiome | 217 | |
| chr2:168,660,993–168,662,101 | 205.5 kb | Distal (>10kb) Multiome HiCAR | 210 |
Genomic view of the CERS6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.