Predicted to enable U2 snRNA binding activity and calmodulin binding activity. Involved in negative regulation of cilium assembly and regulation of mitotic spindle assembly. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP97. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP97 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP97, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,466,683–101,467,491 | 257.5 kb | Distal (>10kb) Multiome | 289 | |
| chr3:101,512,475–101,513,632 | 211.5 kb | Distal (>10kb) Multiome | 799 | |
| chr3:101,530,192–101,530,904 | 194.1 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,561,343–101,562,162 | 162.8 kb | Distal (>10kb) Multiome | 783 | |
| chr3:101,573,305–101,575,121 | 150.5 kb | Distal (>10kb) Multiome | 1039 | |
| chr3:101,641,500–101,642,206 | 82.8 kb | Distal (>10kb) Multiome | 397 | |
| chr3:101,724,220–101,725,851 | 182 bp | At TSS Multiome | 749 | |
| chr3:101,778,676–101,779,992 | 54.7 kb | Distal (>10kb) Multiome | 826 | |
| chr3:101,848,739–101,850,257 | 124.8 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the CEP97 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.