The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CEP72. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP72 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP72, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:320,742–322,619 | 290.7 kb | Distal (>10kb) Multiome | 441 | |
| chr5:472,056–474,135 | 139.2 kb | Distal (>10kb) Multiome HiCAR | 964 | |
| chr5:523,794–524,758 | 88.1 kb | Distal (>10kb) Multiome | 106 | |
| chr5:611,543–612,836 | 88 bp | At TSS Multiome | 508 | |
| chr5:693,160–693,784 | 81.1 kb | Distal (>10kb) Multiome | 258 | |
| chr5:784,104–785,298 | 172.5 kb | Distal (>10kb) Multiome | 316 | |
| chr5:892,342–893,335 | 280.5 kb | Distal (>10kb) Multiome | 802 |
Genomic view of the CEP72 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.