Enables phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole; centrosome; and procentriole. Part of procentriole replication complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP192. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP192 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP192, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,702,219–12,703,287 | 288.6 kb | Distal (>10kb) Multiome | 869 | |
| chr18:12,766,645–12,767,371 | 224.2 kb | Distal (>10kb) Multiome | 392 | |
| chr18:12,776,564–12,778,096 | 214.3 kb | Distal (>10kb) Multiome | 123 | |
| chr18:12,862,247–12,862,768 | 128.8 kb | Distal (>10kb) Multiome | 116 | |
| chr18:12,883,233–12,884,627 | 107.2 kb | Distal (>10kb) Multiome | 904 | |
| chr18:12,946,945–12,948,745 | 43.4 kb | Distal (>10kb) Multiome | 1139 | |
| chr18:12,989,036–12,990,533 | 1.9 kb | Proximal (<10kb) Multiome | 336 | |
| chr18:12,990,680–12,991,971 | 51 bp | At TSS Multiome | 977 | |
| chr18:12,993,548–12,993,744 | 2.2 kb | Proximal (<10kb) | 9 | |
| chr18:12,993,992–12,994,185 | 2.6 kb | Proximal (<10kb) | 10 | |
| chr18:13,003,392–13,003,928 | 12.2 kb | Distal (>10kb) Multiome | 168 | |
| chr18:13,216,871–13,219,231 | 226.1 kb | Distal (>10kb) Multiome | 503 |
Genomic view of the CEP192 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.