Enables protein homodimerization activity. Involved in several processes, including intraciliary transport involved in cilium assembly; protein localization to centrosome; and regulation of centrosome duplication. Located in several cellular components, including ciliary transition zone; intercellular bridge; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CEP131. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP131 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP131, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:80,981,166–80,981,777 | 241.5 kb | Distal (>10kb) Multiome | 249 | |
| chr17:80,991,699–80,992,263 | 231.0 kb | Distal (>10kb) Multiome | 639 | |
| chr17:81,033,927–81,036,743 | 188.0 kb | Distal (>10kb) Multiome | 822 | |
| chr17:81,101,596–81,102,059 | 121.1 kb | Distal (>10kb) Multiome | 815 | |
| chr17:81,222,360–81,223,690 | 203 bp | At TSS Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 16.2 kb | Distal (>10kb) Multiome | 811 | |
| chr17:81,295,024–81,295,658 | 72.3 kb | Distal (>10kb) Multiome | 832 | |
| chr17:81,339,311–81,340,470 | 116.5 kb | Distal (>10kb) Multiome | 474 | |
| chr17:81,345,409–81,347,165 | 123.3 kb | Distal (>10kb) Multiome | 891 | |
| chr17:81,393,141–81,395,575 | 171.1 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 174.4 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 258.6 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 261.5 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 265.0 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 290.0 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 296.6 kb | Distal (>10kb) Multiome | 617 |
Genomic view of the CEP131 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.