This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for CEP112. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP112 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP112, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:65,294,030–65,294,715 | 897.7 kb | Distal (>10kb) Multiome HiCAR | 350 | |
| chr17:65,572,070–65,573,554 | 619.3 kb | Distal (>10kb) Multiome HiCAR | 475 | |
| chr17:65,576,866–65,577,684 | 615.0 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr17:66,191,429–66,192,575 | 12 bp | At TSS Multiome | 745 | |
| chr17:66,301,809–66,303,755 | 110.4 kb | Distal (>10kb) Multiome | 810 | |
| chr17:66,304,453–66,305,188 | 112.8 kb | Distal (>10kb) Multiome | 347 | |
| chr17:66,373,686–66,374,800 | 181.9 kb | Distal (>10kb) Multiome | 271 |
Genomic view of the CEP112 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.