CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CENPP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CENPP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CENPP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:92,114,946–92,115,785 | 210.5 kb | Distal (>10kb) Multiome | 807 | |
| chr9:92,133,789–92,134,516 | 191.8 kb | Distal (>10kb) Multiome | 252 | |
| chr9:92,137,993–92,138,553 | 187.7 kb | Distal (>10kb) Multiome | 237 | |
| chr9:92,140,183–92,140,786 | 185.5 kb | Distal (>10kb) Multiome | 418 | |
| chr9:92,293,467–92,294,114 | 32.1 kb | Distal (>10kb) Multiome | 966 | |
| chr9:92,325,052–92,326,254 | 275 bp | At TSS Multiome | 999 |
Genomic view of the CENPP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.