CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CENPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CENPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CENPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:173,669,068–173,669,991 | 155.2 kb | Distal (>10kb) Multiome | 247 | |
| chr1:173,714,634–173,715,651 | 109.8 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:173,824,030–173,825,369 | 301 bp | At TSS Multiome | 904 | |
| chr1:173,852,512–173,853,711 | 28.2 kb | Distal (>10kb) Multiome | 358 | |
| chr1:173,859,027–173,863,516 | 37.8 kb | Distal (>10kb) Multiome | 578 | |
| chr1:173,866,947–173,869,294 | 43.5 kb | Distal (>10kb) Multiome | 1182 | |
| chr1:174,021,545–174,024,235 | 197.5 kb | Distal (>10kb) Multiome | 1001 |
Genomic view of the CENPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.