This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CENATAC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CENATAC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CENATAC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,714,768–118,715,435 | 283.3 kb | Distal (>10kb) Multiome | 87 | |
| chr11:118,715,577–118,717,605 | 280.9 kb | Distal (>10kb) Multiome | 445 | |
| chr11:118,789,603–118,790,362 | 208.3 kb | Distal (>10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 205.2 kb | Distal (>10kb) Multiome | 958 | |
| chr11:118,907,074–118,907,685 | 90.9 kb | Distal (>10kb) Multiome | 491 | |
| chr11:118,909,181–118,909,816 | 88.8 kb | Distal (>10kb) Multiome | 326 | |
| chr11:118,909,976–118,911,609 | 87.5 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 85.9 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 81.2 kb | Distal (>10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 79.7 kb | Distal (>10kb) Multiome | 522 | |
| chr11:118,925,703–118,926,356 | 72.1 kb | Distal (>10kb) Multiome | 595 | |
| chr11:118,927,947–118,930,852 | 68.7 kb | Distal (>10kb) Multiome | 892 | |
| chr11:118,997,538–118,998,797 | 62 bp | At TSS Multiome | 798 | |
| chr11:119,018,081–119,019,265 | 20.4 kb | Distal (>10kb) Multiome | 897 | |
| chr11:119,029,885–119,031,330 | 32.8 kb | Distal (>10kb) Multiome | 876 | |
| chr11:119,056,436–119,057,778 | 59.1 kb | Distal (>10kb) Multiome | 815 | |
| chr11:119,067,446–119,068,100 | 69.6 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 86.9 kb | Distal (>10kb) Multiome | 846 | |
| chr11:119,093,969–119,096,070 | 97.4 kb | Distal (>10kb) Multiome | 1046 | |
| chr11:119,101,351–119,102,791 | 104.0 kb | Distal (>10kb) Multiome | 871 | |
| chr11:119,106,906–119,107,993 | 109.2 kb | Distal (>10kb) Multiome | 650 | |
| chr11:119,120,857–119,122,037 | 123.3 kb | Distal (>10kb) Multiome | 787 | |
| chr11:119,144,795–119,145,355 | 146.9 kb | Distal (>10kb) Multiome | 230 | |
| chr11:119,148,816–119,149,933 | 151.4 kb | Distal (>10kb) Multiome | 262 | |
| chr11:119,168,601–119,169,645 | 170.8 kb | Distal (>10kb) Multiome | 794 | |
| chr11:119,205,241–119,207,150 | 208.0 kb | Distal (>10kb) Multiome | 695 |
Genomic view of the CENATAC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.