This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for CELF5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CELF5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CELF5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,739,625–2,740,374 | 484.5 kb | Distal (>10kb) Multiome HiCAR | 1063 | |
| chr19:2,944,631–2,945,468 | 279.6 kb | Distal (>10kb) Multiome | 891 | |
| chr19:2,950,070–2,951,291 | 273.9 kb | Distal (>10kb) Multiome | 962 | |
| chr19:2,976,688–2,977,848 | 247.3 kb | Distal (>10kb) Multiome | 715 | |
| chr19:2,983,511–2,984,586 | 240.6 kb | Distal (>10kb) Multiome | 523 | |
| chr19:3,024,668–3,025,742 | 199.5 kb | Distal (>10kb) Multiome | 159 | |
| chr19:3,035,442–3,037,057 | 188.2 kb | Distal (>10kb) Multiome | 947 | |
| chr19:3,041,823–3,042,438 | 182.4 kb | Distal (>10kb) Multiome | 173 | |
| chr19:3,045,731–3,048,029 | 178.7 kb | Distal (>10kb) Multiome | 612 | |
| chr19:3,062,260–3,062,861 | 162.1 kb | Distal (>10kb) Multiome | 369 | |
| chr19:3,093,786–3,095,227 | 130.5 kb | Distal (>10kb) Multiome | 515 | |
| chr19:3,095,637–3,096,163 | 128.7 kb | Distal (>10kb) Multiome | 256 | |
| chr19:3,185,437–3,186,577 | 38.9 kb | Distal (>10kb) Multiome | 751 | |
| chr19:3,224,482–3,224,897 | 20 bp | At TSS Multiome | 253 | |
| chr19:3,275,036–3,277,129 | 51.6 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,284,276–3,286,396 | 60.9 kb | Distal (>10kb) Multiome | 555 | |
| chr19:3,360,114–3,360,563 | 135.6 kb | Distal (>10kb) Multiome | 430 | |
| chr19:3,434,837–3,435,636 | 210.5 kb | Distal (>10kb) Multiome | 777 | |
| chr19:3,441,686–3,442,206 | 217.3 kb | Distal (>10kb) Multiome | 86 | |
| chr19:3,444,085–3,444,710 | 219.8 kb | Distal (>10kb) Multiome | 150 | |
| chr19:3,500,403–3,501,074 | 276.1 kb | Distal (>10kb) Multiome | 886 | |
| chr19:3,505,575–3,507,061 | 281.4 kb | Distal (>10kb) Multiome | 838 | |
| chr19:3,557,019–3,558,238 | 333.0 kb | Distal (>10kb) Multiome | 811 | |
| chr19:3,572,147–3,574,664 | 348.1 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,576,363–3,578,543 | 353.6 kb | Distal (>10kb) Multiome | 346 |
Genomic view of the CELF5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.