The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for CDT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,533,022–88,535,493 | 269.7 kb | Distal (>10kb) Multiome | 458 | |
| chr16:88,569,589–88,571,104 | 233.5 kb | Distal (>10kb) Multiome | 904 | |
| chr16:88,634,178–88,635,155 | 169.2 kb | Distal (>10kb) Multiome | 384 | |
| chr16:88,650,385–88,651,684 | 152.7 kb | Distal (>10kb) Multiome | 890 | |
| chr16:88,662,399–88,664,138 | 140.6 kb | Distal (>10kb) Multiome | 943 | |
| chr16:88,686,082–88,687,017 | 117.3 kb | Distal (>10kb) Multiome | 675 | |
| chr16:88,705,859–88,706,820 | 97.4 kb | Distal (>10kb) Multiome | 838 | |
| chr16:88,737,237–88,737,815 | 66.2 kb | Distal (>10kb) Multiome | 619 | |
| chr16:88,769,688–88,770,137 | 34.0 kb | Distal (>10kb) Multiome | 282 | |
| chr16:88,770,700–88,771,325 | 32.7 kb | Distal (>10kb) Multiome | 668 | |
| chr16:88,784,542–88,785,880 | 18.4 kb | Distal (>10kb) Multiome | 811 | |
| chr16:88,802,766–88,805,068 | 110 bp | At TSS Multiome | 881 | |
| chr16:88,810,968–88,812,892 | 8.3 kb | Proximal (<10kb) Multiome | 1059 | |
| chr16:88,856,080–88,858,003 | 53.2 kb | Distal (>10kb) Multiome | 885 | |
| chr16:88,940,964–88,942,110 | 138.1 kb | Distal (>10kb) Multiome | 323 | |
| chr16:89,093,591–89,094,129 | 290.1 kb | Distal (>10kb) Multiome | 694 | |
| chr16:89,167,237–89,167,783 | 363.8 kb | Distal (>10kb) Multiome HiCAR | 740 | |
| chr16:89,170,902–89,172,416 | 367.8 kb | Distal (>10kb) Multiome HiCAR | 464 |
Genomic view of the CDT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.