Transcription factors with Perturb-seq knockdown data for CDK6-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK6-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK6-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,589,648–92,590,940 | 246.2 kb | Distal (>10kb) Multiome HiCAR | 1025 | |
| chr7:92,608,546–92,609,216 | 227.6 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr7:92,763,629–92,764,462 | 72.5 kb | Distal (>10kb) Multiome | 433 | |
| chr7:92,832,617–92,837,194 | 2.5 kb | Proximal (<10kb) Multiome | 1121 | |
| chr7:92,840,359–92,840,625 | 3.9 kb | Proximal (<10kb) | 28 | |
| chr7:92,848,440–92,849,238 | 12.2 kb | Distal (>10kb) Multiome | 136 | |
| chr7:92,880,092–92,880,930 | 44.1 kb | Distal (>10kb) Multiome | 192 | |
| chr7:92,925,995–92,927,027 | 90.0 kb | Distal (>10kb) Multiome | 201 | |
| chr7:93,006,288–93,007,025 | 170.1 kb | Distal (>10kb) Multiome | 128 | |
| chr7:93,043,277–93,044,576 | 207.2 kb | Distal (>10kb) Multiome | 356 |
Genomic view of the CDK6-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.