This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for CDK19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:110,618,379–110,619,138 | 196.7 kb | Distal (>10kb) Multiome | 186 | |
| chr6:110,786,496–110,787,137 | 28.6 kb | Distal (>10kb) Multiome | 18 | |
| chr6:110,814,145–110,816,325 | 215 bp | At TSS Multiome | 1024 | |
| chr6:110,873,984–110,876,719 | 60.9 kb | Distal (>10kb) Multiome | 1070 | |
| chr6:110,958,321–110,959,190 | 143.2 kb | Distal (>10kb) Multiome | 984 | |
| chr6:110,981,592–110,982,485 | 166.6 kb | Distal (>10kb) Multiome | 968 | |
| chr6:111,033,760–111,034,293 | 218.6 kb | Distal (>10kb) Multiome | 47 | |
| chr6:111,087,119–111,088,655 | 272.0 kb | Distal (>10kb) Multiome | 637 | |
| chr6:111,091,616–111,092,325 | 276.4 kb | Distal (>10kb) Multiome | 90 |
Genomic view of the CDK19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.