CDK11B
cyclin dependent kinase 11B | CDK11-p110, CDK11-p46, CDK11-p58, CDC2L1

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Member of: DE-1
Biological processes 46 terms
ATP binding (GO:0005524)ATP binding (GO:0005524)RNA binding (GO:0003723)RNA polymerase II CTD heptapeptide repeat S2 kinase activity (GO:0140834)RNA polymerase II CTD heptapeptide repeat S5 kinase activity (GO:0140836)RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)RNA polymerase II promoter clearance (GO:0001111)apoptotic process (GO:0006915)chromosome (GO:0005694)chromosome (GO:0005694)chromosome, centromeric region (GO:0000775)chromosome, centromeric region (GO:0000775)cyclin L-CDK11 complex (GO:0180038)cyclin-dependent protein kinase holoenzyme complex (GO:0000307)cyclin-dependent protein serine/threonine kinase activity (GO:0004693)cyclin-dependent protein serine/threonine kinase activity (GO:0004693)cytoplasm (GO:0005737)cytoplasm (GO:0005737)mitotic cell cycle (GO:0000278)mitotic sister chromatid cohesion, centromeric (GO:0071962)mitotic sister chromatid cohesion, centromeric (GO:0071962)nuclear speck (GO:0016607)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of DNA-templated transcription (GO:0006355)regulation of apoptotic process (GO:0042981)regulation of cell cycle (GO:0051726)regulation of cell cycle (GO:0051726)regulation of cell growth (GO:0001558)regulation of cell growth (GO:0001558)regulation of centrosome cycle (GO:0046605)regulation of mRNA processing (GO:0050684)regulation of mRNA processing (GO:0050684)regulation of mRNA splicing, via spliceosome (GO:0048024)regulation of transcription by RNA polymerase II (GO:0006357)
Expression (TPM)
CDK11B — as a Regulated Gene

TFs regulating CDK11B 0 TFs

Transcription factors with Perturb-seq knockdown data for CDK11B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK11B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CDK11B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK11B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:1,374,767–1,375,798 283.6 kb Distal (>10kb) Multiome 1113
chr1:1,398,861–1,399,955 259.5 kb Distal (>10kb) Multiome 879
chr1:1,406,992–1,407,823 251.7 kb Distal (>10kb) Multiome 938
chr1:1,435,318–1,436,066 223.3 kb Distal (>10kb) Multiome 511
chr1:1,511,442–1,512,404 147.0 kb Distal (>10kb) Multiome 897
chr1:1,540,164–1,541,317 118.4 kb Distal (>10kb) Multiome 195
chr1:1,573,904–1,575,432 84.2 kb Distal (>10kb) Multiome 949
chr1:1,599,945–1,600,642 59.0 kb Distal (>10kb) Multiome 307
chr1:1,615,103–1,616,799 43.5 kb Distal (>10kb) Multiome 951
chr1:1,628,379–1,632,529 28.9 kb Distal (>10kb) Multiome 552
chr1:1,658,722–1,659,418 119 bp At TSS Multiome 602
chr1:1,724,054–1,724,738 65.4 kb Distal (>10kb) Multiome 631
chr1:1,777,637–1,780,173 119.7 kb Distal (>10kb) Multiome 970
chr1:1,782,008–1,783,229 123.3 kb Distal (>10kb) Multiome 590
chr1:1,883,184–1,883,831 224.6 kb Distal (>10kb) Multiome 303
chr1:1,890,319–1,891,952 232.3 kb Distal (>10kb) Multiome 748
chr1:1,908,308–1,910,312 250.2 kb Distal (>10kb) Multiome 801
chr1:1,918,258–1,920,500 260.4 kb Distal (>10kb) Multiome 820

Genome Browser

Genomic view of the CDK11B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:1,364,767 – 1,930,500
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact