This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for CDK11A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK11A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK11A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,435,318–1,436,066 | 288.7 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 212.3 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 183.7 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 149.5 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 124.3 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 108.8 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 94.2 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 65.2 kb | Distal (>10kb) Multiome | 602 | |
| chr1:1,724,054–1,724,738 | 114 bp | At TSS Multiome | 631 | |
| chr1:1,777,637–1,780,173 | 54.4 kb | Distal (>10kb) Multiome | 970 | |
| chr1:1,782,008–1,783,229 | 58.0 kb | Distal (>10kb) Multiome | 590 | |
| chr1:1,883,184–1,883,831 | 159.3 kb | Distal (>10kb) Multiome | 303 | |
| chr1:1,890,319–1,891,952 | 167.0 kb | Distal (>10kb) Multiome | 748 | |
| chr1:1,908,308–1,910,312 | 184.9 kb | Distal (>10kb) Multiome | 801 | |
| chr1:1,918,258–1,920,500 | 195.1 kb | Distal (>10kb) Multiome | 820 | |
| chr1:1,959,901–1,960,517 | 235.9 kb | Distal (>10kb) Multiome | 594 | |
| chr1:2,019,137–2,019,982 | 295.2 kb | Distal (>10kb) Multiome | 288 |
Genomic view of the CDK11A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.