This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for CDCP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDCP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDCP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:44,861,375–44,862,600 | 284.5 kb | Distal (>10kb) Multiome | 765 | |
| chr3:44,975,358–44,976,703 | 170.2 kb | Distal (>10kb) Multiome | 732 | |
| chr3:45,145,719–45,146,718 | 31 bp | At TSS Multiome | 356 | |
| chr3:45,224,890–45,226,655 | 78.8 kb | Distal (>10kb) Multiome | 505 | |
| chr3:45,388,133–45,389,048 | 242.1 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the CDCP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.