This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for CDC73. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC73 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC73, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:192,808,061–192,809,823 | 313.1 kb | Distal (>10kb) Multiome HiCAR | 926 | |
| chr1:193,058,504–193,060,296 | 62.5 kb | Distal (>10kb) Multiome | 1176 | |
| chr1:193,104,306–193,105,941 | 16.6 kb | Distal (>10kb) Multiome | 926 | |
| chr1:193,113,187–193,113,979 | 8.5 kb | Proximal (<10kb) Multiome | 295 | |
| chr1:193,121,459–193,122,720 | 31 bp | At TSS Multiome | 1102 | |
| chr1:193,415,736–193,416,952 | 294.4 kb | Distal (>10kb) Multiome | 144 |
Genomic view of the CDC73 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.