The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC14A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC14A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC14A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:100,132,347–100,133,463 | 219.5 kb | Distal (>10kb) Multiome HiCAR | 947 | |
| chr1:100,249,217–100,250,325 | 102.6 kb | Distal (>10kb) Multiome HiCAR | 803 | |
| chr1:100,265,673–100,266,819 | 86.2 kb | Distal (>10kb) Multiome | 796 | |
| chr1:100,337,594–100,338,776 | 14.3 kb | Distal (>10kb) Multiome | 109 | |
| chr1:100,350,909–100,353,664 | 36 bp | At TSS Multiome | 1006 | |
| chr1:100,354,062–100,354,259 | 1.6 kb | Proximal (<10kb) | 166 | |
| chr1:100,355,010–100,355,180 | 2.5 kb | Proximal (<10kb) | 223 | |
| chr1:100,360,538–100,361,084 | 8.1 kb | Proximal (<10kb) | 268 | |
| chr1:100,361,696–100,362,070 | 9.2 kb | Proximal (<10kb) | 46 | |
| chr1:100,439,928–100,440,470 | 87.8 kb | Distal (>10kb) Multiome | 293 | |
| chr1:100,538,654–100,540,350 | 187.3 kb | Distal (>10kb) Multiome | 481 |
Genomic view of the CDC14A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.