Enables ATP binding activity and magnesium ion binding activity. Involved in eukaryotic translation initiation factor 2 complex assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDC123. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC123 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC123, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:11,913,209–11,913,675 | 282.7 kb | Distal (>10kb) Multiome | 34 | |
| chr10:12,041,862–12,043,685 | 153.1 kb | Distal (>10kb) Multiome | 849 | |
| chr10:12,063,340–12,063,818 | 132.6 kb | Distal (>10kb) Multiome | 219 | |
| chr10:12,068,387–12,069,409 | 127.3 kb | Distal (>10kb) Multiome | 831 | |
| chr10:12,129,046–12,130,594 | 66.6 kb | Distal (>10kb) Multiome | 734 | |
| chr10:12,195,567–12,196,550 | 109 bp | At TSS Multiome | 929 | |
| chr10:12,264,254–12,264,720 | 68.3 kb | Distal (>10kb) Multiome | 542 | |
| chr10:12,348,533–12,350,063 | 153.2 kb | Distal (>10kb) Multiome | 473 | |
| chr10:12,444,721–12,445,267 | 248.7 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the CDC123 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.