Enables several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Involved in DNA cytosine deamination and cytidine deamination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CDADC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDADC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDADC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:48,975,109–48,976,919 | 271.4 kb | Distal (>10kb) Multiome | 933 | |
| chr13:49,184,188–49,185,149 | 63.1 kb | Distal (>10kb) Multiome | 84 | |
| chr13:49,218,368–49,219,071 | 29.2 kb | Distal (>10kb) Multiome | 51 | |
| chr13:49,219,748–49,221,361 | 27.7 kb | Distal (>10kb) Multiome | 441 | |
| chr13:49,237,761–49,238,093 | 9.8 kb | Proximal (<10kb) | 8 | |
| chr13:49,247,525–49,248,779 | 14 bp | At TSS Multiome | 752 | |
| chr13:49,280,990–49,281,662 | 33.4 kb | Distal (>10kb) Multiome | 111 | |
| chr13:49,443,422–49,445,325 | 196.2 kb | Distal (>10kb) Multiome | 929 | |
| chr13:49,495,326–49,496,757 | 248.2 kb | Distal (>10kb) Multiome | 729 |
Genomic view of the CDADC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.