This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:20,290,425–20,291,141 | 298.3 kb | Distal (>10kb) Multiome | 203 | |
| chr1:20,342,875–20,344,326 | 245.4 kb | Distal (>10kb) Multiome | 261 | |
| chr1:20,366,975–20,367,437 | 221.8 kb | Distal (>10kb) Multiome | 164 | |
| chr1:20,402,741–20,403,363 | 186.1 kb | Distal (>10kb) Multiome | 165 | |
| chr1:20,430,474–20,430,904 | 158.4 kb | Distal (>10kb) Multiome | 217 | |
| chr1:20,485,233–20,485,959 | 103.4 kb | Distal (>10kb) Multiome | 348 | |
| chr1:20,486,131–20,487,438 | 102.3 kb | Distal (>10kb) Multiome | 760 | |
| chr1:20,493,822–20,494,241 | 95.0 kb | Distal (>10kb) Multiome | 430 | |
| chr1:20,507,717–20,508,432 | 81.0 kb | Distal (>10kb) Multiome | 811 | |
| chr1:20,552,019–20,553,890 | 36.7 kb | Distal (>10kb) Multiome | 518 | |
| chr1:20,588,675–20,590,358 | 89 bp | At TSS Multiome | 431 | |
| chr1:20,625,186–20,625,881 | 36.4 kb | Distal (>10kb) Multiome | 123 | |
| chr1:20,633,024–20,634,989 | 44.8 kb | Distal (>10kb) Multiome | 759 | |
| chr1:20,661,099–20,662,130 | 72.5 kb | Distal (>10kb) Multiome | 784 | |
| chr1:20,696,319–20,697,384 | 107.8 kb | Distal (>10kb) Multiome | 727 | |
| chr1:20,717,384–20,718,370 | 128.8 kb | Distal (>10kb) Multiome | 440 | |
| chr1:20,731,726–20,733,330 | 143.1 kb | Distal (>10kb) Multiome | 718 | |
| chr1:20,786,021–20,787,857 | 197.9 kb | Distal (>10kb) Multiome | 963 |
Genomic view of the CDA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.