This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CD99L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD99L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD99L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:150,693,098–150,694,049 | 205.1 kb | Distal (>10kb) Multiome | 435 | |
| chrX:150,898,166–150,899,720 | 74 bp | At TSS Multiome | 562 | |
| chrX:150,902,225–150,902,784 | 3.9 kb | Proximal (<10kb) Multiome | 187 | |
| chrX:150,903,174–150,903,379 | 4.5 kb | Proximal (<10kb) | 25 | |
| chrX:150,982,738–150,984,074 | 84.5 kb | Distal (>10kb) Multiome | 454 | |
| chrX:151,082,143–151,082,818 | 183.8 kb | Distal (>10kb) Multiome | 346 | |
| chrX:151,175,898–151,178,232 | 277.8 kb | Distal (>10kb) Multiome | 212 |
Genomic view of the CD99L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.