The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for CD83. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD83 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD83, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:13,859,849–13,861,074 | 257.2 kb | Distal (>10kb) Multiome | 81 | |
| chr6:13,873,408–13,874,382 | 243.9 kb | Distal (>10kb) Multiome | 915 | |
| chr6:13,923,928–13,925,299 | 193.0 kb | Distal (>10kb) Multiome | 566 | |
| chr6:14,117,134–14,118,295 | 74 bp | At TSS Multiome | 640 | |
| chr6:14,210,686–14,212,342 | 93.5 kb | Distal (>10kb) Multiome | 895 | |
| chr6:14,296,854–14,297,404 | 179.4 kb | Distal (>10kb) Multiome | 23 |
Genomic view of the CD83 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.