This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for CD55. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD55 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD55, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:207,032,411–207,033,137 | 288.8 kb | Distal (>10kb) Multiome | 345 | |
| chr1:207,050,462–207,051,643 | 270.7 kb | Distal (>10kb) Multiome | 707 | |
| chr1:207,052,563–207,053,810 | 268.5 kb | Distal (>10kb) Multiome | 863 | |
| chr1:207,316,696–207,317,348 | 4.3 kb | Proximal (<10kb) | 409 | |
| chr1:207,320,849–207,322,455 | 130 bp | At TSS Multiome | 996 | |
| chr1:207,453,941–207,454,999 | 132.7 kb | Distal (>10kb) Multiome | 525 | |
| chr1:207,579,217–207,579,858 | 257.9 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the CD55 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.