This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for CD300E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD300E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD300E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,325,836–74,326,504 | 297.5 kb | Distal (>10kb) Multiome | 237 | |
| chr17:74,351,773–74,352,296 | 271.8 kb | Distal (>10kb) Multiome | 202 | |
| chr17:74,379,476–74,379,948 | 244.1 kb | Distal (>10kb) Multiome | 522 | |
| chr17:74,414,550–74,415,075 | 208.9 kb | Distal (>10kb) Multiome | 72 | |
| chr17:74,431,757–74,432,660 | 191.5 kb | Distal (>10kb) Multiome | 791 | |
| chr17:74,453,513–74,454,652 | 169.6 kb | Distal (>10kb) Multiome | 751 | |
| chr17:74,642,311–74,642,966 | 19.2 kb | Distal (>10kb) Multiome | 119 | |
| chr17:74,643,823–74,644,224 | 20.5 kb | Distal (>10kb) Multiome | 17 | |
| chr17:74,671,047–74,671,700 | 47.7 kb | Distal (>10kb) Multiome | 938 | |
| chr17:74,736,296–74,738,156 | 113.6 kb | Distal (>10kb) Multiome | 797 | |
| chr17:74,744,666–74,745,585 | 121.1 kb | Distal (>10kb) Multiome | 580 | |
| chr17:74,745,827–74,747,102 | 122.9 kb | Distal (>10kb) Multiome | 213 | |
| chr17:74,748,109–74,749,683 | 124.8 kb | Distal (>10kb) Multiome | 915 | |
| chr17:74,775,871–74,776,940 | 152.6 kb | Distal (>10kb) Multiome | 798 | |
| chr17:74,842,511–74,843,541 | 219.2 kb | Distal (>10kb) Multiome | 412 | |
| chr17:74,852,259–74,853,211 | 228.9 kb | Distal (>10kb) Multiome | 435 | |
| chr17:74,872,506–74,873,926 | 249.4 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:74,893,600–74,894,183 | 270.0 kb | Distal (>10kb) Multiome | 189 | |
| chr17:74,923,198–74,923,804 | 299.8 kb | Distal (>10kb) Multiome | 543 |
Genomic view of the CD300E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.