The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for CD276. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD276 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD276, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:73,632,366–73,634,024 | 50.9 kb | Distal (>10kb) Multiome | 802 | |
| chr15:73,636,471–73,636,966 | 47.8 kb | Distal (>10kb) Multiome | 427 | |
| chr15:73,677,176–73,677,350 | 7.0 kb | Proximal (<10kb) | 136 | |
| chr15:73,683,662–73,685,097 | 90 bp | At TSS Multiome | 641 | |
| chr15:73,733,109–73,733,828 | 49.1 kb | Distal (>10kb) Multiome | 33 | |
| chr15:73,752,465–73,753,181 | 68.5 kb | Distal (>10kb) Multiome | 192 | |
| chr15:73,926,301–73,928,142 | 243.4 kb | Distal (>10kb) Multiome | 557 | |
| chr15:73,964,793–73,965,395 | 280.6 kb | Distal (>10kb) Multiome | 395 | |
| chr15:73,972,958–73,973,626 | 288.8 kb | Distal (>10kb) Multiome | 375 |
Genomic view of the CD276 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.