This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for CD200. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD200 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD200, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,048,832–112,049,452 | 284.0 kb | Distal (>10kb) Multiome | 163 | |
| chr3:112,085,739–112,087,192 | 246.7 kb | Distal (>10kb) Multiome | 690 | |
| chr3:112,126,419–112,126,878 | 206.4 kb | Distal (>10kb) Multiome | 150 | |
| chr3:112,136,789–112,137,394 | 196.0 kb | Distal (>10kb) Multiome | 233 | |
| chr3:112,293,399–112,294,560 | 39.3 kb | Distal (>10kb) Multiome | 304 | |
| chr3:112,302,106–112,304,027 | 29.7 kb | Distal (>10kb) Multiome | 204 | |
| chr3:112,321,650–112,322,563 | 11.0 kb | Distal (>10kb) Multiome | 210 | |
| chr3:112,327,480–112,327,656 | 5.5 kb | Proximal (<10kb) | 128 | |
| chr3:112,332,491–112,332,611 | 536 bp | At TSS | 4 | |
| chr3:112,332,830–112,333,873 | 86 bp | At TSS Multiome | 281 | |
| chr3:112,336,259–112,336,605 | 3.1 kb | Proximal (<10kb) | 36 | |
| chr3:112,390,974–112,391,552 | 58.2 kb | Distal (>10kb) Multiome | 215 | |
| chr3:112,399,211–112,401,142 | 67.4 kb | Distal (>10kb) Multiome | 175 | |
| chr3:112,560,905–112,563,207 | 229.0 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the CD200 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.