This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for CD164. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD164 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD164, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:109,094,199–109,095,904 | 287.6 kb | Distal (>10kb) Multiome | 1009 | |
| chr6:109,186,108–109,187,056 | 196.0 kb | Distal (>10kb) Multiome HiCAR | 39 | |
| chr6:109,236,275–109,236,762 | 145.9 kb | Distal (>10kb) Multiome | 258 | |
| chr6:109,381,700–109,383,452 | 210 bp | At TSS Multiome | 1036 | |
| chr6:109,383,781–109,384,695 | 1.3 kb | Proximal (<10kb) | 369 | |
| chr6:109,440,119–109,441,745 | 58.3 kb | Distal (>10kb) Multiome | 863 | |
| chr6:109,454,912–109,456,586 | 73.5 kb | Distal (>10kb) Multiome | 733 | |
| chr6:109,482,359–109,484,058 | 100.9 kb | Distal (>10kb) Multiome | 675 | |
| chr6:109,678,985–109,679,628 | 296.8 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the CD164 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.