This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for CD109. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD109 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD109, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,450,878–73,452,652 | 244.1 kb | Distal (>10kb) Multiome | 510 | |
| chr6:73,461,207–73,462,355 | 234.5 kb | Distal (>10kb) Multiome | 806 | |
| chr6:73,511,142–73,516,574 | 181.9 kb | Distal (>10kb) Multiome | 913 | |
| chr6:73,520,105–73,522,117 | 174.9 kb | Distal (>10kb) Multiome | 1220 | |
| chr6:73,579,484–73,580,917 | 115.8 kb | Distal (>10kb) Multiome | 828 | |
| chr6:73,653,023–73,654,818 | 42.2 kb | Distal (>10kb) Multiome | 944 | |
| chr6:73,695,662–73,696,526 | 69 bp | At TSS Multiome | 534 | |
| chr6:73,697,373–73,697,554 | 1.2 kb | Proximal (<10kb) | 79 | |
| chr6:75,204,283–75,209,417 | 1509.9 kb | Distal (>10kb) Multiome HiCAR | 741 | |
| chr6:75,243,188–75,244,541 | 1547.6 kb | Distal (>10kb) Multiome HiCAR | 858 | |
| chr6:75,334,164–75,335,181 | 1638.6 kb | Distal (>10kb) Multiome HiCAR | 265 |
Genomic view of the CD109 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.