The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for CCT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:69,330,668–69,333,363 | 252.7 kb | Distal (>10kb) Multiome | 710 | |
| chr12:69,359,411–69,360,582 | 225.5 kb | Distal (>10kb) Multiome HiCAR | 990 | |
| chr12:69,470,012–69,471,069 | 115.1 kb | Distal (>10kb) Multiome | 831 | |
| chr12:69,583,229–69,583,510 | 1.9 kb | Proximal (<10kb) | 69 | |
| chr12:69,585,221–69,586,062 | 102 bp | At TSS Multiome | 1005 | |
| chr12:69,738,320–69,740,119 | 153.3 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the CCT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.