Enables microtubule binding activity. Involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Located in axon; ciliary transition zone; and cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCSAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCSAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCSAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:228,647,259–228,648,459 | 695.3 kb | Distal (>10kb) Multiome HiCAR | 684 | |
| chr1:229,090,571–229,091,190 | 252.5 kb | Distal (>10kb) Multiome | 31 | |
| chr1:229,093,644–229,094,437 | 249.2 kb | Distal (>10kb) Multiome | 253 | |
| chr1:229,203,285–229,203,797 | 139.7 kb | Distal (>10kb) Multiome | 237 | |
| chr1:229,270,652–229,271,643 | 72.1 kb | Distal (>10kb) Multiome | 892 | |
| chr1:229,342,012–229,343,421 | 681 bp | At TSS Multiome | 829 | |
| chr1:229,507,825–229,508,800 | 165.0 kb | Distal (>10kb) Multiome | 885 | |
| chr1:229,557,924–229,559,481 | 215.7 kb | Distal (>10kb) Multiome | 985 | |
| chr1:229,625,075–229,626,774 | 282.8 kb | Distal (>10kb) Multiome | 894 |
Genomic view of the CCSAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.