CCNK

cyclin K | CPR4

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

Member of: DE-10

Biological processes 25 terms

DNA damage response (GO:0006974)RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)cyclin K-CDK12 complex (GO:0002944)cyclin K-CDK13 complex (GO:0002945)cyclin-dependent protein kinase holoenzyme complex (GO:0000307)cyclin-dependent protein serine/threonine kinase activator activity (GO:0061575)cyclin-dependent protein serine/threonine kinase activity (GO:0004693)cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)cyclin/CDK positive transcription elongation factor complex (GO:0008024)host-mediated suppression of viral genome replication (GO:0044828)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription, elongation (GO:0032786)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)protein binding (GO:0005515)protein kinase binding (GO:0019901)regulation of cell cycle (GO:0051726)regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)regulation of signal transduction (GO:0009966)regulation of transcription by RNA polymerase II (GO:0006357)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)

Expression (TPM)

TFs regulating CCNK 0 TFs

Transcription factors with Perturb-seq knockdown data for CCNK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CCNK

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:99,230,631–99,232,582	249.3 kb	Distal (>10kb) Multiome	274
chr14:99,245,498–99,247,127	235.4 kb	Distal (>10kb) Multiome	314
chr14:99,262,920–99,263,579	218.3 kb	Distal (>10kb) Multiome	160
chr14:99,270,416–99,271,381	210.6 kb	Distal (>10kb) Multiome	301
chr14:99,271,901–99,274,036	208.0 kb	Distal (>10kb) Multiome	584
chr14:99,274,138–99,275,258	206.6 kb	Distal (>10kb) Multiome	708
chr14:99,479,847–99,482,007	259 bp	At TSS Multiome	803
chr14:99,580,183–99,580,635	99.0 kb	Distal (>10kb) Multiome	170
chr14:99,602,979–99,605,771	123.0 kb	Distal (>10kb) Multiome	993
chr14:99,663,812–99,664,749	182.9 kb	Distal (>10kb) Multiome	215
chr14:99,682,774–99,684,994	201.4 kb	Distal (>10kb) Multiome	763
chr14:99,729,847–99,731,033	248.8 kb	Distal (>10kb) Multiome	551

Genome Browser

Genomic view of the CCNK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.