The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for CCNH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:87,267,003–87,269,320 | 145.1 kb | Distal (>10kb) Multiome | 917 | |
| chr5:87,411,949–87,413,601 | 42 bp | At TSS Multiome | 809 | |
| chr5:88,659,646–88,661,615 | 1248.2 kb | Distal (>10kb) Multiome HiCAR | 570 | |
| chr5:88,671,570–88,672,534 | 1259.1 kb | Distal (>10kb) Multiome HiCAR | 221 | |
| chr5:88,674,048–88,676,457 | 1263.1 kb | Distal (>10kb) Multiome HiCAR | 679 | |
| chr5:88,680,113–88,681,161 | 1267.6 kb | Distal (>10kb) Multiome HiCAR | 559 | |
| chr5:88,684,266–88,685,701 | 1272.0 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr5:88,690,452–88,691,491 | 1278.1 kb | Distal (>10kb) Multiome HiCAR | 454 |
Genomic view of the CCNH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.