The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CCNE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,638,867–94,642,864 | 256.0 kb | Distal (>10kb) Multiome | 705 | |
| chr8:94,719,362–94,720,432 | 175.4 kb | Distal (>10kb) Multiome | 1182 | |
| chr8:94,822,329–94,823,941 | 72.0 kb | Distal (>10kb) Multiome | 818 | |
| chr8:94,894,252–94,897,051 | 1.6 kb | Proximal (<10kb) Multiome | 927 | |
| chr8:94,948,413–94,950,514 | 54.2 kb | Distal (>10kb) Multiome | 850 | |
| chr8:95,024,342–95,025,424 | 129.7 kb | Distal (>10kb) Multiome | 980 | |
| chr8:95,132,764–95,134,804 | 238.5 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the CCNE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.