This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for CCL28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCL28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCL28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,064,252–43,065,217 | 332.3 kb | Distal (>10kb) Multiome HiCAR | 959 | |
| chr5:43,065,881–43,067,664 | 330.6 kb | Distal (>10kb) Multiome HiCAR | 928 | |
| chr5:43,105,415–43,106,204 | 291.5 kb | Distal (>10kb) Multiome | 820 | |
| chr5:43,120,453–43,122,435 | 275.9 kb | Distal (>10kb) Multiome | 1097 | |
| chr5:43,191,656–43,192,908 | 205.1 kb | Distal (>10kb) Multiome HiCAR | 475 | |
| chr5:43,312,549–43,314,340 | 83.6 kb | Distal (>10kb) Multiome | 954 | |
| chr5:43,389,590–43,390,036 | 7.2 kb | Proximal (<10kb) | 384 | |
| chr5:43,396,119–43,396,550 | 713 bp | At TSS | 52 | |
| chr5:43,396,804–43,397,322 | 134 bp | At TSS Multiome | 340 | |
| chr5:43,483,333–43,484,741 | 86.6 kb | Distal (>10kb) Multiome | 1033 | |
| chr5:43,514,568–43,515,502 | 117.9 kb | Distal (>10kb) Multiome | 817 | |
| chr5:43,555,878–43,557,718 | 159.6 kb | Distal (>10kb) Multiome | 936 | |
| chr5:43,602,369–43,604,281 | 205.8 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the CCL28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.