This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for CCDC88B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC88B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC88B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,165,638–64,166,698 | 176.5 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 156.8 kb | Distal (>10kb) Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 116.5 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 112.2 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 108.2 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 101.4 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 95.6 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 91.3 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 72.6 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 71.1 kb | Distal (>10kb) Multiome | 595 | |
| chr11:64,284,095–64,286,666 | 57.0 kb | Distal (>10kb) Multiome | 807 | |
| chr11:64,300,129–64,301,268 | 41.7 kb | Distal (>10kb) Multiome | 591 | |
| chr11:64,304,032–64,307,072 | 36.4 kb | Distal (>10kb) Multiome | 994 | |
| chr11:64,316,954–64,319,418 | 23.7 kb | Distal (>10kb) Multiome | 1039 | |
| chr11:64,340,711–64,341,211 | 1.8 kb | Proximal (<10kb) Multiome | 212 | |
| chr11:64,342,083–64,343,227 | 55 bp | At TSS Multiome | 543 | |
| chr11:64,343,904–64,344,079 | 1.2 kb | Proximal (<10kb) | 81 | |
| chr11:64,355,132–64,355,542 | at TSS | At TSS | 605 | |
| chr11:64,358,792–64,359,751 | 16.4 kb | Distal (>10kb) Multiome | 577 | |
| chr11:64,448,870–64,449,995 | 106.3 kb | Distal (>10kb) Multiome | 490 | |
| chr11:64,630,081–64,630,643 | 287.6 kb | Distal (>10kb) Multiome | 226 | |
| chr11:64,637,888–64,638,531 | 295.5 kb | Distal (>10kb) Multiome | 168 |
Genomic view of the CCDC88B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.