Predicted to enable fibronectin binding activity and heparin binding activity. Predicted to be involved in extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region; interstitial matrix; and membrane. Predicted to be active in basement membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC80. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC80 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC80, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,390,974–112,391,552 | 249.8 kb | Distal (>10kb) Multiome | 215 | |
| chr3:112,399,211–112,401,142 | 240.6 kb | Distal (>10kb) Multiome | 175 | |
| chr3:112,560,905–112,563,207 | 79.1 kb | Distal (>10kb) Multiome | 967 | |
| chr3:112,640,471–112,641,320 | at TSS | At TSS | 349 | |
| chr3:112,642,951–112,643,248 | 1.8 kb | Proximal (<10kb) | 274 | |
| chr3:112,647,103–112,647,656 | 6.0 kb | Proximal (<10kb) | 227 | |
| chr3:112,990,506–112,991,646 | 350.0 kb | Distal (>10kb) Multiome HiCAR | 925 |
Genomic view of the CCDC80 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.