Transcription factors with Perturb-seq knockdown data for CCDC71L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC71L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC71L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:106,176,499–106,177,243 | 484.3 kb | Distal (>10kb) Multiome HiCAR | 473 | |
| chr7:106,417,157–106,417,851 | 243.6 kb | Distal (>10kb) Multiome | 177 | |
| chr7:106,653,021–106,653,188 | 8.0 kb | Proximal (<10kb) | 29 | |
| chr7:106,659,669–106,661,551 | 943 bp | At TSS Multiome | 898 | |
| chr7:106,841,951–106,842,683 | 181.1 kb | Distal (>10kb) Multiome | 140 |
Genomic view of the CCDC71L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.