Predicted to enable microtubule binding activity. Involved in spindle midzone assembly. Located in spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC69. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC69 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC69, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:151,020,249–151,021,200 | 203.5 kb | Distal (>10kb) Multiome | 522 | |
| chr5:151,080,524–151,081,640 | 143.0 kb | Distal (>10kb) Multiome | 916 | |
| chr5:151,157,085–151,158,664 | 66.3 kb | Distal (>10kb) Multiome | 760 | |
| chr5:151,214,158–151,214,458 | 9.6 kb | Proximal (<10kb) | 357 | |
| chr5:151,223,077–151,224,282 | 54 bp | At TSS Multiome | 662 | |
| chr5:151,252,199–151,253,942 | 28.9 kb | Distal (>10kb) Multiome | 746 | |
| chr5:151,447,360–151,448,441 | 223.6 kb | Distal (>10kb) Multiome | 900 | |
| chr5:151,500,606–151,501,090 | 276.8 kb | Distal (>10kb) Multiome | 332 |
Genomic view of the CCDC69 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.