Enables identical protein binding activity and microtubule binding activity. Involved in centriole assembly and mitotic spindle assembly. Located in centriolar satellite and ciliary basal body. Part of centriolar subdistal appendage. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC61. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC61 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC61, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,716,851–45,718,343 | 278.0 kb | Distal (>10kb) Multiome | 895 | |
| chr19:45,730,200–45,731,219 | 264.5 kb | Distal (>10kb) Multiome | 740 | |
| chr19:45,767,223–45,771,892 | 224.7 kb | Distal (>10kb) Multiome | 1161 | |
| chr19:45,779,258–45,780,150 | 215.9 kb | Distal (>10kb) Multiome | 445 | |
| chr19:45,792,338–45,793,273 | 202.6 kb | Distal (>10kb) Multiome | 609 | |
| chr19:45,815,484–45,818,073 | 179.6 kb | Distal (>10kb) Multiome | 623 | |
| chr19:45,862,559–45,864,765 | 132.3 kb | Distal (>10kb) Multiome | 976 | |
| chr19:45,881,480–45,883,645 | 112.5 kb | Distal (>10kb) Multiome | 990 | |
| chr19:45,885,092–45,887,294 | 108.8 kb | Distal (>10kb) Multiome | 913 | |
| chr19:45,901,212–45,903,471 | 92.6 kb | Distal (>10kb) Multiome | 780 | |
| chr19:45,952,967–45,953,485 | 42.4 kb | Distal (>10kb) Multiome | 329 | |
| chr19:45,973,761–45,974,227 | 21.4 kb | Distal (>10kb) Multiome | 201 | |
| chr19:45,994,774–45,995,740 | 201 bp | At TSS Multiome | 660 | |
| chr19:45,999,631–46,000,096 | 4.2 kb | Proximal (<10kb) | 219 | |
| chr19:46,000,993–46,001,197 | 5.5 kb | Proximal (<10kb) | 88 | |
| chr19:46,014,941–46,015,784 | 20.0 kb | Distal (>10kb) Multiome | 220 | |
| chr19:46,016,414–46,017,078 | 21.5 kb | Distal (>10kb) Multiome | 364 | |
| chr19:46,076,819–46,077,882 | 82.2 kb | Distal (>10kb) Multiome | 516 | |
| chr19:46,133,049–46,133,620 | 138.0 kb | Distal (>10kb) Multiome | 189 |
Genomic view of the CCDC61 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.