Involved in several processes, including G2/M transition of mitotic cell cycle; cilium assembly; and microtubule cytoskeleton organization. Located in centriolar satellite; centriole; and spindle microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC57. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC57 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC57, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,917,586–81,918,522 | 294.7 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 289.3 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 285.0 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 275.5 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 253.1 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 244.8 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 235.2 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 192.7 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 189.8 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 180.9 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 175.2 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 161.1 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 147.0 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 114.3 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 109.3 kb | Distal (>10kb) Multiome | 672 | |
| chr17:82,205,955–82,206,129 | 6.7 kb | Proximal (<10kb) | 653 | |
| chr17:82,212,405–82,213,592 | 44 bp | At TSS Multiome | 911 | |
| chr17:82,228,266–82,232,536 | 16.1 kb | Distal (>10kb) Multiome | 1048 | |
| chr17:82,272,608–82,274,062 | 60.8 kb | Distal (>10kb) Multiome | 943 | |
| chr17:82,278,488–82,279,226 | 66.1 kb | Distal (>10kb) Multiome | 229 | |
| chr17:82,292,400–82,293,256 | 80.1 kb | Distal (>10kb) Multiome | 944 | |
| chr17:82,414,581–82,415,044 | 202.0 kb | Distal (>10kb) Multiome | 799 | |
| chr17:82,417,993–82,419,018 | 205.7 kb | Distal (>10kb) Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 238.0 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 245.7 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 281.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 284.5 kb | Distal (>10kb) Multiome | 613 |
Genomic view of the CCDC57 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.