Implicated in brain cancer and high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:127,733,783–127,736,880 | 1946.0 kb | Distal (>10kb) Multiome HiCAR | 1123 | |
| chr8:128,982,795–128,983,351 | 699.1 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr8:129,515,453–129,516,252 | 166.4 kb | Distal (>10kb) Multiome | 248 | |
| chr8:129,681,927–129,682,490 | at TSS | At TSS | 386 | |
| chr8:129,687,500–129,687,704 | 5.4 kb | Proximal (<10kb) | 109 | |
| chr8:129,832,812–129,833,944 | 151.4 kb | Distal (>10kb) Multiome | 175 | |
| chr8:129,939,023–129,940,545 | 257.8 kb | Distal (>10kb) Multiome | 936 |
Genomic view of the CCDC26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.