Transcription factors with Perturb-seq knockdown data for CCDC192. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC192 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC192, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:127,517,064–127,518,431 | 221.9 kb | Distal (>10kb) Multiome | 880 | |
| chr5:127,739,352–127,740,200 | at TSS | At TSS | 147 | |
| chr5:127,934,861–127,935,426 | 195.6 kb | Distal (>10kb) Multiome | 524 | |
| chr5:127,941,166–127,941,443 | 5.9 kb | Proximal (<10kb) | 44 | |
| chr5:127,941,636–127,941,904 | 6.4 kb | Proximal (<10kb) | 68 |
Genomic view of the CCDC192 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.