Transcription factors with Perturb-seq knockdown data for CCDC171. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC171 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC171, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:15,306,092–15,307,952 | 245.7 kb | Distal (>10kb) Multiome | 885 | |
| chr9:15,354,632–15,356,131 | 198.1 kb | Distal (>10kb) Multiome | 170 | |
| chr9:15,422,127–15,423,372 | 130.3 kb | Distal (>10kb) Multiome | 914 | |
| chr9:15,510,031–15,511,595 | 42.0 kb | Distal (>10kb) Multiome | 913 | |
| chr9:15,512,558–15,513,923 | 39.7 kb | Distal (>10kb) Multiome | 289 | |
| chr9:15,529,900–15,530,578 | 22.8 kb | Distal (>10kb) Multiome | 210 | |
| chr9:15,551,866–15,553,797 | 16 bp | At TSS Multiome | 898 | |
| chr9:15,554,022–15,554,359 | 980 bp | At TSS | 18 | |
| chr9:15,554,436–15,554,750 | 1.4 kb | Proximal (<10kb) | 26 |
Genomic view of the CCDC171 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.