Transcription factors with Perturb-seq knockdown data for CCDC150. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC150 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC150, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:196,592,181–196,593,965 | 46.7 kb | Distal (>10kb) Multiome | 567 | |
| chr2:196,637,316–196,637,665 | 2.0 kb | Proximal (<10kb) | 4 | |
| chr2:196,639,223–196,641,327 | 38 bp | At TSS Multiome | 902 | |
| chr2:196,799,143–196,800,218 | 160.0 kb | Distal (>10kb) Multiome | 1098 | |
| chr2:196,925,547–196,927,652 | 287.2 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the CCDC150 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.